IMHO, with regards to the OP's original question, yes, however there is a steep learning curve in getting things to run perfectly. Fortunately, with a mild combo, very little needs to be tweaked; things like MAF curve, injector slopes, injector breakpoint, throttle body airflow, perhaps some timing curve adjustment. As the mods become more extreme with additional displacement and/or forced induction, there is no choice but to reprogram the computer.
I, as others, have spent several decades tuning carbs and over a decade tuning Ford EECs now. I take great pleasure in my tuning efforts, but I have spent countless hours researching and discussing on this forum and others how to solve specific problems. The end result is always sweet, but it requires patience, persistence, and resourcefulness.
'89 5.0L LX hatch: all 90mm 2.2L Blowzilla Dart Iron Eagle 306 @ 8.4:1, ported Vic Jr heads, TMoss ported GT40 lower, Deka 80# injectors, EDIS8, GUFB-A9L2-Moates tuned, Tremec 3550, 3.31 gears w/31-spline TruTrac
'66 GT 2+2 Fastback: carb'd 289, Canfield heads - EFI transformation pending
'71 Mach 1: totaled - R.I.P.