Run along the passenger side if you can do it safely. I agree that 5 inches is more than enough spacing for heat.
I have a single 4.5 inch down the passenger side by the drive shaft area and it dumps at the back axle to comply with full exhaust street rules. My fuel line is along the frame rail toward the DS. No issues and I dump a LOT of heat down that pipe, plus have a belly pan and air dam up front restricting air under the car.
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89 LX. 363, single turbo, Super Vic EFI, TFS high port heads by TEA, solid roller, glide. Holley HP EFI. (exact combo varies)